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心理旌旗灯号丈量

大鼠.小鼠无创血压仪MRBP

工夫:2016-09-29泉源:本站作者:玉研仪器

具体引见

大小鼠无创血压丈量体系(合适对大鼠小鼠停止无创式的血压丈量,经由过程对鼠尾根部的及时检测,准确丈量出大鼠、小鼠的收缩压、舒张压、均匀压、心率,敬请来电征询)


美国IITC生命科学仪器公司成立于1973年,其血压丈量体系应用于环球的生命科学研究范畴,经由络续的革新和拓展无创血压丈量体系和测痛产物系列,其产物已用于环球实验室,也被数千篇国际论文所援用。

 

MRBP血压丈量体系可以或许丈量起码一只,最多同时200只植物,是经由考证的异常有用的手腕和数据采集法,能够实在辅佐研究人员快速正确的正在最低的推荐温度下对植物停止血压丈量。


大小鼠无创血压丈量体系的重要上风及特性:


Ø 唯一的可测量从小鼠、大鼠、豚鼠到猴的血压装备

Ø 接纳光电传感手艺丈量道理,适用于麻醉、苏醒状况下的植物血压丈量

Ø 内置软件,经由过程触摸操纵屏掌握,操纵轻易。也可经由过程电脑掌握。

Ø 丈量参数:收缩压、舒张压、均匀压、心率等

Ø 充放气速度1-10 mmHg/秒可调

Ø 主动充放气,尾套气压限值和测试停止压力值都可调,进步测试效力

Ø 血压丈量局限:0-300mmHg,精确度±5mmHg

Ø 心率丈量局限:0-1000 bpm插mm,日mm,插mma片96,不消播放器的成人片在线寓目

Ø 液晶屏及时显现参数丈量值和脉搏波形,并能存储、编纂、打印数据

Ø USB间接贮存数据功用

Ø 可一次性自力或同时测试多至200只植物

Ø 适用于核磁共振前提(MRI


MRBP大小鼠血压计的重要特征:

 

无创血压实行需求进步受测体周围环境的温度。理论上,较下温度时,丈量血压的结果很好。我们能够经由过程掌握鼠尾的血量去掌握大小鼠的体温。当体温高于正常值时,流经鼠尾的血液就会散掉过剩的热量。体温越下流经鼠尾的血液就越多。研讨发明,加热大鼠的温度高于32摄氏度、小鼠温度高于34摄氏度时,会产生热应力,植物的热量便会丧失一部分。那便影响了真正的血压值(改动了差不多+/-12-28 mmHg


检测脉冲的情势非常重要,而传感器的挑选决意了建造工艺。压电传感器多年来被普遍应用于麦克风和触碰开关。其道理是:对传感器施加外力后,发生电信号。但用这类传感器作为检测脉冲会有一系列的题目和缺点:停止血压丈量时有较下的温度需求(36-40℃)。

用晶体做的脉冲探测器也会泛起一些题目和缺点:停止鼠类的血压丈量时所需求的温度高于热力学程度温度(36-40℃),并且加热尾部是基于尾部脉搏是部分加热的效果那一毛病的假定。


1978IITC发清楚明了光电传感器,它将光和图片传感器用于脉搏的丈量。当血流经由过程尾部,尾部血管直径的改动致使了光量得改动,间接致使光电量的转变。IITC原件的设想(感到电子设备和咬合袖带)不会像其他仪器一样,会对鼠尾发生机器性的作用力,同时若是需求能够准确天割断传感器。光电传感器能够正在关闭的室温下停止检测,事实上很多运用本产物宣布过的论文中,小鼠的起测温度要低于28℃,大鼠以至更低。


与其他的高温法相比:

鼠类和其他植物一样有一个内涵的调治机制,我们称为“温度调治。一般的环境温度也许正在26-27℃,若是环境温度高于一般温度(28-30℃),温度调治最先增添血液流量。如许会致使尾部会有更多的血液流量,因为尾部是身材的一部分而其实不是简朴的皮革的掩盖,以是会自行降温以求尽快散热。那就是直接丈量血压的道理。

MRBP大小鼠血压计最大的差别在于脉搏探测器上。它能正在26℃大概更低的温度下停止丈量。而其他脉搏探测器因为不敷敏感便会要求更高的温度。温度过高会使植物殒命的风险大大增添。


大小鼠无创血压仪的局部参考文献:

Geraniol improves endothelial function by inhibiting NOX-2 derived oxidative stress in high fat diet fed mice

X Wang, S Zhao, M Su, L Sun, S Zhang, D Wang… - Biochemical and …, 2016 - Elsevier

... HFD controls; n = 20) for 6 weeks. After 6 weeks, systolic blood pressure was measured
using tail cuff plethysmography (IITC Life Science MRBP Blood Pressure System). The
mice were deeply anaesthetized with sodium pentobarbital ...

Disruption of calpain reduces lipotoxicity-induced cardiac injury by preventing endoplasmic reticulum stress

S Li, L Zhang, R Ni, T Cao, D Zheng, S Xiong… - … et Biophysica Acta (BBA …, 2016 - Elsevier

... Animals were acclimated in the environment for 5–10 min after occlusion cuffs and pulse
transducers (,丁香蒲月啪啪,激情综合,色久久,色久久综合网,MRBP system, IITC Life Science, USA) were placed on the tail. The values of
at least 10 readings for each mouse were used for blood pressure. 2.4. ...

Influence of P2X receptors on renal medullary circulation is not altered by angiotensin II pretreatment

M Kuczeriszka, L Dobrowolski, A Walkowska… - Pharmacological …, 2016 - Elsevier

... We confirmed that with this procedure systolic blood pressure (tail-cuff method,
MRBP-3R, IITC Inc., Woodland Hills, CA, USA) increased gradually to about 190 mmHg,
compared to about 130 mmHg measured in untreated SD rats. ...

Protective Effects of At1-Receptor Blocker and Ca Antagonist Combination on Renal Function in Salt Loaded Spontaneously Hypertensive Rats/Протективни Ефекти …

K Gjorgjievska, D Zafirov, M Jurhar-Pavlova… - prilozi, 2015 - degruyter.com

... function tests. SBP was measured by a pletismografic method (IITC Life Science
MRBP Blood Pressure System, California, USA) on the rats tail. Body weight was
measured every second week of treatment. Renal functional ...

The Synthetic Tie2 Agonist Peptide Vasculotide Protects Renal Vascular Barrier Function In Experimental Acute Kidney Injury

E Rübig, J Stypmann, P Van Slyke, DJ Dumont… - Scientific …, 2016 - ncbi.nlm.nih.gov插mm,日mm,插mma片96,不消播放器的成人片在线寓目

... Immediately before the first ultrasound examination, average blood pressure and heart rate
were measured via tail cuff in each animal (5 measurements) using the mouse blood pressure
system MRBP-M01 (IITC Life science, Woodland Hills, CA, USA). ...

Changes in protein and gene expression of angiotensin II receptors (AT1 and AT2) in aorta of diabetic and hypertensive rats

R Romero-Nava, JE Rodriguez… - Clinical and …, 2016 - Taylor & Francis

... Systolic blood pressure (SBP) and heart rate were measured by a non-invasive blood pressure
tail-cuff method (MRBP Blood Pressure system, IITC, Life Science, Woodland Hills, CA) by
photoelectric detection in the rat tail and blood glucose levels were measured with a ...

Low-dose Insulin Treatment Ameliorate Glucose Metabolism in Type 1 Diabetic Rats. J Diabetes Metab 7: 635. doi: 10.4172/2155-6156.1000 635 Page 2 of 8 …

AXH Ng, SH Ton, KA Kadir - 2016 - researchgate.net

... The blood pressure of rats were measured once every week using the MRBP Mouse and Rat
Tail Cuff Method Blood Pressure System (IITC Life Sciences, USA). The tail cuff with pulse
transducer was applied onto the tail of the rat placed in a plastic restrainer. ...

Benefício da Utilização do Novo Alimento Funcional Salgante sem Sódio sobre os Níveis de Pressão Arterial em Animais Hipertensos

FSM Rodrigues, MA Yasuda, L de Paula… - Revista de Pesquisa …, 2015 - pgsskroton.com.br

... Os parâmetros foram aferidos através de método não invasivo (indireto) utilizando equipamento
MRBP (Mouse Rat Blood Pressure- IITC Life Science) nos dias zero (sem tratamento com NaCl
ou Salgante - pó de aspecto cristalino, branco e fino, solúvel em água, com odor ...

 

 

Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressureulcers

B Fromy, E Lingueglia, D Sigaudo-Roussel… - Nature medicine,丁香蒲月啪啪,激情综合,色久久,色久久综合网,nature.com

... The experimental protocol was approved by the scientific and ethics committees of the University
Claude Bernard Lyon 1, France (no. ... Blood pressure was monitored noninvasively throughout
the experiment using a tail cuff system (IITC INC/Life Science Instruments). ..

Nature Medicine,五年影响因子高达27.887

Salt–sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor

CRJ Kennedy, Y Zhang, S Brandon, Y Guan… - Nature medicine, 1999 - nature.com

... Mouse blood pressure was measured using an IITC Life Science Model 27 cuff pump with a
Model 179 blood pressure analyzer. Pressure was measured at 30 °C and was initiated as
cuffs were inflated to 200 mm Hg and deflated at a rate of 3 mm Hg/sec. ...


Chronic β-adrenergic stimulation induces myocardial proinflammatory cytokine expression

DR Murray, SD Prabhu, B Chandrasekar - Circulation, 2000 - Am Heart Assoc

... System–Audie Murphy Division, San Antonio, Tex (DRM, BC), and the University of Louisville
Health Sciences Center, Louisville ... 1 · d −1 , n=8) or saline (n=7). After anesthesia, measures
of body weight, blood pressure, and heart rate (tail cuff, IITC Life Science model 29 ...

 

Circulation 最新的影响因子为15.202 (2013) ,该杂志 2011年正在 CARDIAC & CARDIOVASCULAR SYSTEMS (心血管) 同类期刊中的影响因子排名第 1位。

Endogenous Ligand of α1 Sodium Pump, Marinobufagenin, Is a Novel Mediator of Sodium Chloride–Dependent Hypertension

OV Fedorova, MI Talan, NI Agalakova, EG Lakatta… - Circulation, 2002 - Am Heart Assoc

... Systolic BP (SBP) was measured weekly by tail-cuff plethysmography (IITC model 31, IITC Life
Science). ... 1969; 1 (suppl 24, 25): 21–33. ↵ Blaustein MP. Sodium ions, calcium ions, blood
pressure regulation and hypertension: a reassessment and a hypothesis. Am J Physiol. ...

 

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